Bivalirudin hepatic or renal clearance
WebApr 9, 2024 · This study compared the effects of bivalirudin and UFH on liver/renal function in patients with coronary artery disease who underwent CAG, with or without PCI. ... Compared with UFH or glycoprotein IIb/IIIa inhibitors, the clearance of bivalirudin is less dependent on renal function,2 and bivalirudin is characterized by rapid onset and fewer ... WebThe majority of patients with acute coronary syndromes have renal impairment from either the aging process or from underlying disease, such as nephrosclerosis or diabetes. For example, in the phase 3 studies of bivalirudin use in PTCA, only 25% of patients had normal renal function: 46% had mild ren …
Bivalirudin hepatic or renal clearance
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WebBivalirudin (Hirulog ®, Angiomax ) is a specific, reversible and direct thrombin in-hibitor with a predictable anticoagulant effect. It is cleared by both proteolytic cleavage and renal … WebMar 1, 2024 · The disposition of bivalirudin was studied in PTCA patients with mild, moderate and severe renal impairment. The clearance of bivalirudin was reduced approximately 21% in patients with moderate and severe renal impairment and was reduced approximately 70% in dialysis-dependent patients [see Clinical Pharmacology ].
WebMar 20, 2024 · Usual Adult Dose for Percutaneous Coronary Intervention. For patients who do not have heparin-induced thrombocytopenia (HIT) or heparin-induced … WebSep 1, 2011 · Bivalirudin is regularly dose reduced in the setting of renal dysfunction because of its known partial renal clearance. 11 However, dosing guidance for patients supported by CRRT while on ECMO is ...
WebTraductions en contexte de "fonction hépatique ou rénale altérée" en français-anglais avec Reverso Context : Une hypogycémie grave peut résulter avec la prise de tous médicaments sulfonylurées. Les personnes les plus exposées sont les aînés, les personnes fragiles ou mal nourries et celles ayant une fonction hépatique ou rénale altérée. WebBivalirudin is cleared from plasma by a combination of renal mechanisms and proteolytic cleavage Half-life: -Normal renal function (≥ 90 mL/min) = 25 minutes -Mild renal …
WebOct 17, 2024 · Bivalirudin is a direct thrombin inhibitor that may require lower doses to reach therapeutic targets in patients receiving renal replacement therapy . While a small …
Webbivalirudin on liver and kidney function in patients subjected to these procedures. This study compared the effects of bi-valirudin and UFH on liver/renal function in patients with coronary artery disease who underwent CAG, with or with-out PCI. Methods: The study comprised 134 consecutive patients (40–89 years-old), who underwent CAG (or CAG irest massage chair bbbWebIts clearance exceeded hepatic or renal blood flow suggesting metabolic clearance. At 24 h after i.v. administration of [3H] ... Bivalirudin is cleared partly by a renal mechanism (glomerular filtration) and, there-fore, its dose needs to be adjusted in patients with renal impairment (43,44). The half-life. CLINICAL APPLICATIONS ((Acute ... ordering lateral flow tests for childrenWebTherefore, severe renal impairment and hepatic impairment both cause a reduction in its rate of clearance [81,82]. From: Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. ... Patients with moderate and severe renal impairment have reductions in bivalirudin clearance. An analyses of data for 4312 patients with unstable angina showed ... ordering lateral flow test kits nhs scotlandWebBivalirudin is a 20 amino-acids hirudin-analogue with a molecular mass of 2’180 Da and a half-life of ~25 minutes; it is eliminated by proteolysis and for ~20% by renal clearance . Both bind human thrombin reversibly, … ordering lateral flow test kits nhs staffWebClearance is reduced approximately 20% in patients with moderate and severe renal impairment and by 80% in dialysis-dependent patients; Bivalirudin is hemodialyzable and approximately 25% is cleared by hemodialysis. Pharmacodynamics. Coagulation times return to baseline approximately 1 hour following cessation of bivalirudin administration. irestore githubWebMay 23, 2024 · Bivalirudin does not bind to plasma proteins (other than thrombin) or to red blood cells. Elimination. Bivalirudin has a half-life of 25 minutes in PTCA patients with normal renal function. The total body … ordering lateral flow test niWebA recommended alternative to heparin, bivalirudin, has its own disadvantages, including the lack of a reversal agent ... likely through decreased renal clearance and/or decreased hepatic blood flow and drug metabolism. Thus, although all animals finished 120 min of bypass without evidence of thrombus formation, we cannot say that the targeted ... ordering lateral flow test kits nhs worker